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In conclusion, dietary supplements are a vital category of pharmaceutical APIs that offer a convenient and effective way to supplement nutritional intake and promote overall well-being

119 Moreover, the phosphorylation of ULK1 at Ser555 by AMPK is required for proper mitochondrial homeostasis

10 More recently, several other agents have demonstrated clinical activity in HCC and have been incorporated into and adopted by major HCC guidelines, including lenvatinib 11 (multi-kinase inhibitor of VEGF, fibroblast growth factor, and PDGF pathways) in frontline and cabozantinib 12 (multi-kinase inhibitor of Met and VEGF pathways), regorafenib 13 (multi-kinase inhibitor of VEGF and angiopoietin receptor pathways), and ramucirumab 14 (anti-VEGF receptor 2 antibody) in the second-line setting

This narrative review critically synthesizes current evidence regarding the evolving biological basis of HG and evaluates established and emerging therapeutic strategies